L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

Name	Val-cit-PAB-OH
Synonyms	EOS-61316 VAL-CIT-PAB Val-cit-PAB-OH NH2-Val-Cit-PAB (D)-VAL-CIT-PAB L-Valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- (S)-2-((R)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide (S)-2-((S)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide
CAS	159857-79-1
EINECS	826-617-2

Molecular Formula	C18H29N5O4
Molar Mass	379.45
Density	1.243±0.06 g/cm3(Predicted)
Melting Point	168 °C(dec.)
Boling Point	715.0±60.0 °C(Predicted)
Solubility	DMSO :59 mg/mL (155.49 mM)
pKa	13.75±0.46(Predicted)
Storage Condition	2-8°C(protect from light)
Physical and Chemical Properties	Bioactive Val-cit-PAB-OH is a degradable ADC linker.
Use	The VAL-CIT-PAB is used as a reagent to prepare cell penetrating peptide GRP78 ligand for tumor cell-specific prodrug therapy, and to prepare monomethylvaline derivative ligand and antibody for cancer therapy.

Raw Materials	L-Ornithinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- H-Cit-PABA Boc-Val-Cit-PABA FMOC-L-Valine L-Citrulline L-Ornithine, N5-(aMinocarbonyl)-N2-[N-[(9H-fluoren-9-ylMethoxy)carbonyl]-L-valyl]- FMOC-VAL-OPFP FMoc-Val-Cit-PAB FMOC-VAL-OSU Fmoc-Cit-PABA
Downstream Products	MC-Val-Cit-PAB L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-

Last Update：2024-01-02 23:10:35

Use	VAL-CIT-PAB is used as a reagent to prepare the cell penetrating peptide GRP78 ligand for tumor cell-specific prodrug therapy, and to prepare monomethylvaline derivative ligands and antibodies for cancer treatment.
biological activity	Val-cit-PAB-OH is a degradable ADC linker.
target	Cleavable

Last Update：2024-04-09 21:54:55

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Product Name: Val-cit-PAB-OH Visit Supplier Webpage Request for quotation
CAS: 159857-79-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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Raw Materials for L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

FMoc-Val-Cit-PAB
Fmoc-Cit-PABA

Downstream Products for L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- Request for Quotation